A New Hope for the Treatment of #Atrial_Fibrillation: Application of #Pulsed-Field #Ablation Technology
by Zhen Wang 1,2,Ming Liang
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110819, China
Submission received: 4 April 2024 / Revised: 17 May 2024 / Accepted: 23 May 2024 / Published: 5 June 2024
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Abstract
In recent years, the prevalence of and mortality associated with #cardiovascular_diseases have been rising
in most countries and regions. AF is the most common arrhythmic condition, and there are
several treatment options for AF. Pulmonary vein isolation is an effective treatment for AF and
is the cornerstone of current ablation techniques, which have one major limitation:
even when diagnosed and treated at a facility that specializes in ablation, patients have
a greater chance of recurrence. Therefore, there is a need to develop better ablation techniques
for the treatment of AF. This article first compares the current cryoablation (CBA) and
radiofrequency ablation (RFA) techniques for the treatment of AF and discusses the utility and
advantages of the development of pulsed-field ablation (PFA) technology.
The current research on PFA is summarized from three perspectives, namely, simulation experiments,
animal experiments, and clinical studies. The results of different stages of
experiments are summarized, especially during animal studies, where pulmonary vein isolation
was carried out effectively without causing injury to the phrenic
nerve, esophagus,
and #pulmonary_veins, with higher safety and shorter incision times. This paper focuses
on a review of various a priori and clinical studies of this new technique for the treatment of AF.
Keywords: atrial fibrillation; ablation technology; simulation study; pulsed electric
field ablation; biological experiment
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